Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Prostanoids vs pentoxifylline

Adverse events (participants) · people with critical limb ischaemia

It is very uncertain whether prostanoids changes adverse events (participants) compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids vs naftidrofuryl

Adverse events (participants) · people with critical limb ischaemia

Prostanoids showed no clear difference in adverse events (participants) compared with naftidrofuryl (low certainty).

1 finding from 1 review

PGE1 vs inositol niacinate

Adverse events (participants) · people with critical limb ischaemia

PGE1 showed no clear difference in adverse events (participants) compared with inositol niacinate (low certainty).

1 finding from 1 review

Iloprost vs PGE1

Adverse events (participants) · people with critical limb ischaemia

Iloprost probably leads to higher adverse events (participants) compared with PGE1 (moderate certainty).

1 finding from 1 review

Prostanoids vs placebo

Adverse events (participants) · people with critical limb ischaemia

Prostanoids probably leads to higher adverse events (participants) compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Serious adverse events WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in serious adverse events WMD of compared with placebo (moderate certainty).

1 finding from 1 review