Cochrane · systematic review · CD011526
Smectite for acute infectious diarrhoea in children
Pérez‐Gaxiola, G, Cuello‐García, CA, Florez, ID, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
7
No studies
2
Included studies
NR
No studies 2 · 22.2%Ungraded 0 · 0%Very low 1 · 11.1%Low 5 · 55.6%Moderate 1 · 11.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Smectite compared to control for acute infectious diarrhoea in children
Population: acute infectious diarrhoea in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Duration of diarrhoea Smectite vs control | no estimate extracted | 14 studies · 2209 participants | Low Downgraded: risk of bias, inconsistency |
Clinical resolution at day 3 Smectite vs control | RR 2.1 [1.3, 3.39] | 5 studies · 312 participants | Low Downgraded: risk of bias, inconsistency |
Stool frequency Smectite vs control | no estimate extracted | 3 studies · 954 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Stool output Smectite vs control | no estimate extracted | 3 studies · 634 participants | Low Downgraded: imprecision |
Need for hospitalization Smectite vs control | RR 0.93 [0.75, 1.15] | 2 studies · 885 participants | Low Downgraded: risk of bias, imprecision |
Need for intravenous access for rehydration Smectite vs control | RR 0.77 [0.54, 1.11] | 1 study · 81 participants | Moderate Downgraded: imprecision |
Adverse events – constipation Smectite vs control | RR 4.71 [0.56, 39.19] | 2 studies · 128 participants | Low Downgraded: risk of bias, imprecision |
Death Smectite vs control | no estimate extracted | NR | No studies |
Serious adverse events Smectite vs control | no estimate extracted | NR | No studies |