Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

16 questions · 17 findings · 6 reviews · Schizophrenia

No studies found 3 · 17.6%GRADE not reported 1 · 5.9%Very low 4 · 23.5%Low 3 · 17.6%Moderate 6 · 35.3%High 0 · 0%

CLOZAPINE vs Typical antipsychotics

Weight gain · patients with schizophrenia

CLOZAPINE probably leads to higher adverse effects 5. Weight gain compared with TYPICAL ANTIPSYCHOTICS (moderate certainty).

2 findings from 1 review

QUETIAPINE vs RISPERIDONE

Adverse effects: 3. Metabolic weight gain ≥7% of total body weight · schizophrenia

QUETIAPINE showed no clear difference in adverse effects: 3. Metabolic weight gain ≥7% of total body weight compared with RISPERIDONE (moderate certainty).

1 finding from 1 review

SULPIRIDE AUGMENTATION OF ANY ANTIPSYCHOTIC DRUG vs antipsychotics

Adverse events: Specific: Weight gain ‐ all doses of depot risperidone ‐ short term Spontaneous reporting by study participants · patients with schizophrenia

SULPIRIDE AUGMENTATION OF ANY ANTIPSYCHOTIC DRUG may leads to lower specific adverse effects: 3a. Endocrine system ‐ short term ‐ weight… compared with ANY ANTIPSYCHOTIC DRUG (low certainty).

1 finding from 1 review