Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

347 questions · 355 findings · 51 reviews

No studies found 135 · 38%GRADE not reported 45 · 12.7%Very low 90 · 25.4%Low 63 · 17.7%Moderate 15 · 4.2%High 7 · 2%

Surgical vs conservative interventions

Treatment failure (indication for non‐routine secondary surgery) · adults (aged ≥ 16 years) with acute middle third clavicle fractures

Surgical may leads to lower treatment failuref Indication for non‐routine secondary surgery compared with conservative interventions (low certainty).

1 finding from 1 review

Surgical vs conservative interventions

Total of participants with adverse event outcomel · adults (aged ≥ 16 years) with acute middle third clavicle fractures

It is very uncertain whether surgical changes total of participants with adverse event outcomel compared with conservative interventions (very low certainty).

1 finding from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Short‐term mortality All‐cause mortality either in‐hospital or within 3 months · patients with oesophageal cancer

It is very uncertain whether non‐surgical changes short‐term mortality All‐cause mortality either in‐hospital or… compared with surgical treatment of oesophageal cancer (primary outcomes) (very low certainty).

1 finding from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Long‐term recurrence (> 5 years) · patients with oesophageal cancer

It is very uncertain whether non‐surgical changes long‐term recurrence (binary outcome) Local recurrence, surgical… compared with surgical treatment of oesophageal cancer (secondary outcomes) (very low certainty).

1 finding from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Long‐term recurrence (maximal · patients with oesophageal cancer

Non‐surgical showed no clear difference in long‐term recurrence (time‐to‐event outcome) Local recurrence,… compared with surgical treatment of oesophageal cancer (secondary outcomes) (low certainty).

1 finding from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Proportion with any adverse event within 3 months Any adverse event within 3 months of any severity · patients with oesophageal cancer

It is very uncertain whether non‐surgical changes proportion with any adverse event within 3 months Any adverse event… compared with surgical treatment of oesophageal cancer (secondary outcomes) (very low certainty).

1 finding from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Long‐term mortality (binary outcome) All‐cause mortality for the duration of · patients with oesophageal cancer

Non‐surgical showed no clear difference in long‐term mortality (binary outcome) All‐cause mortality for the… compared with surgical treatment of oesophageal cancer (primary outcomes) (low certainty).

2 findings from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Long‐term mortality (time‐to‐event outcome): chemoradiotherapy versus surgery All‐cause mortality for the duration of · patients with oesophageal cancer

Non‐surgical showed no clear difference in long‐term mortality (time‐to‐event outcome): chemoradiotherapy… compared with surgical treatment of oesophageal cancer (primary outcomes) (low certainty).

2 findings from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Long‐term mortality (time‐to‐event outcome): radiotherapy versus surgery All‐cause mortality for the duration of · patients with oesophageal cancer

It is very uncertain whether non‐surgical changes long‐term mortality (time‐to‐event outcome): radiotherapy versus… compared with surgical treatment of oesophageal cancer (primary outcomes) (very low certainty).

1 finding from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Proportion of participants with 1 or more serious adverse events according to International Conference on Harmonisation Good Clinical Practice (ICH‐GCP) · patients with oesophageal cancer

It is very uncertain whether non‐surgical changes proportion with a serious adverse event within 3 months Serious… compared with surgical treatment of oesophageal cancer (primary outcomes) (very low certainty).

1 finding from 1 review