CLOZAPINE vs Typical antipsychotics: Global state: no improvement ‐ medium termAs defined in each study
CLOZAPINE probably leads to lower global impression: 1. Not clinically improved ‐ short term compared with TYPICAL ANTIPSYCHOTICS (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
CLOZAPINE vs TYPICAL ANTIPSYCHOTICS Global impression: 1. Not clinically improved ‐ short term · patients with schizophrenia CLOZAPINE probably leads to lower global impression: 1. Not clinically improved ‐ short term compared with TYPICAL ANTIPSYCHOTICS (moderate certainty). Clozapine versus typical neuroleptic medication for schizophrenia (2009) · Cochrane Headline outcomes only | RR 0.71 [0.64, 0.79] | 4 studies · 370 participants | Moderate |
CLOZAPINE vs TYPICAL ANTIPSYCHOTICS Global impression: 1. Not clinically improved ‐ long term · patients with schizophrenia CLOZAPINE probably leads to lower global impression: 1. Not clinically improved ‐ long term compared with TYPICAL ANTIPSYCHOTICS (moderate certainty). Clozapine versus typical neuroleptic medication for schizophrenia (2009) · Cochrane Headline outcomes only | RR 0.83 [0.76, 0.91] | 2 studies · 648 participants | Moderate |
CLOZAPINE vs TYPICAL ANTIPSYCHOTICS ‐ OVERALL Global impression: 1. Not clinically improved ‐ short term · patients with schizophrenia CLOZAPINE probably leads to lower global impression: 1. Not clinically improved ‐ short term compared with TYPICAL ANTIPSYCHOTICS ‐ OVERALL (moderate certainty). Clozapine versus typical neuroleptic medication for schizophrenia (2009) · Cochrane Headline outcomes only | RR 0.72 [0.66, 0.79] | 14 studies · 1119 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.