Antibiotics vs placebo: Annual Exacerbation Rates
Antibiotics probably leads to lower rate of exacerbation per patient/year WMD of compared with placebo (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Antibiotics vs placebo Rate of exacerbation per patient/year WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The two larger… Antibiotics probably leads to lower rate of exacerbation per patient/year WMD of compared with placebo (moderate certainty). Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) (2018) · Cochrane Headline outcomes only | Rate ratio 0.67 [0.54, 0.83] | 5 studies · 1384 participants | Moderate |
Antibiotics vs placebo Rate of exacerbation per patient/year (Continuous antibiotic use) · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies… Antibiotics probably leads to lower rate of exacerbation per patient/year (Continuous antibiotic use) compared with placebo (moderate certainty). Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) (2013) · Cochrane Headline outcomes onlyearlier version CD009764.PUB2, superseded | Rate Ratio 0.73 [0.58, 0.91] | 3 studies · 1262 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.