Adults: formoterol/ICS vs salmeterol/ICS: Asthma‐related non‐fatal serious adverse events
Adults: formoterol/ICS showed no clear difference in asthma‐related non‐fatal serious adverse events ‐… compared with salmeterol/ICS (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Adults: formoterol/ICS vs salmeterol/ICS Asthma‐related non‐fatal serious adverse events ‐ formoterol/budesonide vs salmeterol/fluticasone · adults, chronic asthma: asthma‐related serious adverse events Adults: formoterol/ICS showed no clear difference in asthma‐related non‐fatal serious adverse events ‐… compared with salmeterol/ICS (low certainty). Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and… (2021) · Cochrane Headline outcomes only | OR 0.69 [0.37, 1.26] | 7 studies · 5935 participants | Low |
Adults: formoterol/ICS vs salmeterol/ICS Asthma‐related non‐fatal serious adverse events ‐ formoterol/beclomethasone vs salmeterol/fluticasone · adults, chronic asthma: asthma‐related serious adverse events It is very uncertain whether adults: formoterol/ICS changes asthma‐related non‐fatal serious adverse events ‐… compared with salmeterol/ICS (very low certainty). Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and… (2021) · Cochrane Headline outcomes only | OR 1.01 [0.06, 16.24] | 5 studies · 1510 participants | Very low |
Adults: formoterol/ICS vs salmeterol/ICS Asthma related non‐fatal serious adverse events ‐ formoterol/mometasone v's salmeterol/fluticasone · adults, chronic asthma: asthma‐related serious adverse events It is very uncertain whether adults: formoterol/ICS changes asthma related non‐fatal serious adverse events ‐… compared with salmeterol/ICS (very low certainty). Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and… (2021) · Cochrane Headline outcomes only | OR 7 [0.14, 353.37] | 1 study · 722 participants | Very low |
Adults: formoterol/ICS vs salmeterol/ICS Asthma‐related non‐fatal serious adverse events ‐ formoterol/fluticasone vs salmeterol/fluticasone · adults, chronic asthma: asthma‐related serious adverse events It is very uncertain whether adults: formoterol/ICS changes asthma‐related non‐fatal serious adverse events ‐… compared with salmeterol/ICS (very low certainty). Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and… (2021) · Cochrane Headline outcomes only | OR 0.05 [0, 3.1] | 2 studies · 293 participants | Very low |
Adults: formoterol/ICS vs salmeterol/ICS Asthma‐related non‐fatal serious adverse events ‐ formoterol/budesonide vs salmeterol/budesonide · adults, chronic asthma: asthma‐related serious adverse events Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and… (2021) · Cochrane Headline outcomes only | no estimate extracted | 1 study · 229 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an inhaled corticosteroid for… 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.