Antibiotic treatment (benzathine penicillin) vs other antibiotics: Serological cure (4‐fold decrease or greater in non‐treponemal tests titre)
Antibiotic treatment (benzathine penicillin) showed no clear difference in serological cure (4‐fold decrease or greater in non‐treponemal tests… compared with any other antibiotic (procaine benzylpenicillin) (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Antibiotic treatment (benzathine penicillin) vs any other antibiotic (procaine benzylpenicillin) Serological cure (4‐fold decrease or greater in non‐treponemal tests titre) · newborns with congenital syphilis Antibiotic treatment (benzathine penicillin) showed no clear difference in serological cure (4‐fold decrease or greater in non‐treponemal tests… compared with any other antibiotic (procaine benzylpenicillin) (moderate certainty). Antibiotic treatment for newborns with congenital syphilis (2019) · Cochrane Headline outcomes only | RR 1 [0.97, 1.03] | 1 study · 129 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antibiotic treatment for newborns with congenital syphilis 2019 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.