Question · asked by 1 review
Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo: Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale)
- Population
- People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar extraction; 1 complex oral surgery)
- Intervention
- Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction
- Comparison
- placebo
- Outcome
- Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale)
It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes pain (continuous, VAS 0-10 cm, 7th day) compared with placebo (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs Placebo Pain (continuous, VAS 0-10 cm, 7th day) · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1… · 6th to 7th day It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes pain (continuous, VAS 0-10 cm, 7th day) compared with placebo (very low certainty). Antibiotics to prevent complications following tooth extractions (2021) · Cochrane All outcomes | MD -0.26 [-0.59, 0.07] | 4 studies · 422 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes | 2020-04 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.