Gemcitabine plus oxaliplatin vs 5‐fluorouracil plus cisplatin plus radiotherapy: Serious adverse events
- Population
- people with advanced biliary tract carcinomas
- Intervention
- Gemcitabine plus oxaliplatin
- Comparison
- 5‐fluorouracil plus cisplatin plus radiotherapy
- Outcome
- Serious adverse events
It is very uncertain whether gemcitabine plus oxaliplatin changes serious adverse events compared with 5‐fluorouracil plus cisplatin plus radiotherapy (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Gemcitabine plus oxaliplatin vs 5‐fluorouracil plus cisplatin plus radiotherapy Serious adverse events · people with advanced biliary tract carcinomas It is very uncertain whether gemcitabine plus oxaliplatin changes serious adverse events compared with 5‐fluorouracil plus cisplatin plus radiotherapy (very low certainty). Gemcitabine‐based chemotherapy for advanced biliary tract carcinomas (2018) · Cochrane Headline outcomes only | RR 1.5 [0.66, 3.39] | 1 study · 34 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Gemcitabine‐based chemotherapy for advanced biliary tract carcinomas 2018 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Gemcitabine plus oxaliplatin vs 5‐fluorouracil plus folinic acid · people with advanced biliary tract carcinomas · 1 review
- Gemcitabine plus oxaliplatin vs best supportive care · people with advanced biliary tract carcinomas · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.