Question · asked by 1 review
Amitriptyline vs placebo: Relief of burning/discomfort (symptom relief; pain intensity)
- Population
- People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
- Intervention
- Amitriptyline
- Comparison
- placebo
- Outcome
- Relief of burning/discomfort (symptom relief; pain intensity)
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Amitriptyline (antidepressant, 25 mg/day) vs Placebo Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such… · short-term (up to 3 months) Interventions for treating burning mouth syndrome (2016) · Cochrane All outcomes | Bogetto 1999 (amitriptyline) included but data not presented (79% placebo-arm attrition). | 1 study | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes | 2015-12 | Not listed | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Amitriptyline vs placebo · Patients with burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or… · 0 reviews
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.