Question · asked by 1 review
Antihypertensive drug therapy vs placebo or no treatment: Total serious adverse events
- Population
- adults (18 years of age or older) with hypertension‐induced left ventricular hypertrophy
- Intervention
- Antihypertensive drug therapy
- Comparison
- placebo or no treatment
- Outcome
- Total serious adverse events
It is very uncertain whether antihypertensive therapy changes total serious adverse events compared with placebo or no treatment (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Antihypertensive therapy vs placebo or no treatment Total serious adverse events · adults (18 years of age or older) with hypertension‐induced left ventricular hypertrophy It is very uncertain whether antihypertensive therapy changes total serious adverse events compared with placebo or no treatment (very low certainty). Pharmacotherapy for hypertension‐induced left ventricular hypertrophy (2021) · Cochrane Headline outcomes only | RR 1.02 [0.89, 1.16] | 3 studies · 930 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Pharmacotherapy for hypertension‐induced left ventricular hypertrophy 2021 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.