Mycophenolate mofetil vs IV cyclophosphamide: Ovarian failure
It is very uncertain whether mycophenolate mofetil (MMF) changes ovarian failure compared with IV cyclophosphamide (CPA) (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Mycophenolate mofetil (MMF) vs IV cyclophosphamide (CPA) Ovarian failure · patients with induction therapy in lupus nephritis It is very uncertain whether mycophenolate mofetil (MMF) changes ovarian failure compared with IV cyclophosphamide (CPA) (very low certainty). Immunosuppressive treatment for proliferative lupus nephritis (2018) · Cochrane Headline outcomes only | RR 0.36 [0.06, 2.18] | 3 studies · 539 participants | Very low |
MMF vs IV cyclophosphamide Ovarian failure · Patients with induction therapy in lupus nephritis MMF leads to lower ovarian failure compared with IV cyclophosphamide (high certainty). Immunosuppressive treatment for proliferative lupus nephritis (2012) · Cochrane Headline outcomes onlyearlier version CD002922.PUB3, superseded | RR 0.15 [0.03, 0.8] | 2 studies · 498 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Immunosuppressive treatment for proliferative lupus nephritis 2018 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.