Question · asked by 1 review
Statins with cholesterol supplementation vs cholesterol supplementation only: Changes in biochemical markers plasma dehydrocholesterol levels (mM); plasma cholesterol levels (mM); plasma 7DHC levels (mM); plasma CoQ levels (uM); CSF cholesterol levels (ug/mL); CSF dehydrocholesterol levels (ug/mL)
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Statins with cholesterol supplementation vs cholesterol supplementation only Changes in biochemical markers plasma dehydrocholesterol levels (mM); plasma cholesterol levels (mM); plasma 7DHC levels (mM); plasma CoQ levels (uM); CSF cholesterol levels (ug/mL); CSF dehydrocholesterol levels (ug/mL) · children and adults with Smith‐Lemli‐Opitz syndrome Statins for Smith‐Lemli‐Opitz syndrome (2022) · Cochrane Headline outcomes only | no estimate extracted | 1 study · 18 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Statins for Smith‐Lemli‐Opitz syndrome 2022 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.