A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered: HIV transmission at 12 months among infants whose HIV diagnostic testing was negative within 6 weeks of birth and whose mothers were not on HAART
- Population
- Breastfeeding infants of HIV‐infected mothers
- Intervention
- A once‐daily NVP regimen administered for 6 months
- Comparison
- a once‐daily NVP regimen administered
- Outcome
- HIV transmission at 12 months among infants whose HIV diagnostic testing was negative within 6 weeks of birth and whose mothers were not on HAART
A once‐daily NVP regimen administered for 6 months showed no clear difference in HIV transmission at 12 months among infants whose HIV diagnostic… compared with a once‐daily NVP regimen administered (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered HIV transmission at 12 months among infants whose HIV diagnostic testing was negative within 6 weeks of birth and whose mothers were not on HAART · Breastfeeding infants of HIV‐infected mothers A once‐daily NVP regimen administered for 6 months showed no clear difference in HIV transmission at 12 months among infants whose HIV diagnostic… compared with a once‐daily NVP regimen administered (low certainty). Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane Headline outcomes only | HR 0.65 [0.33, 1.28] | 1 study · 1078 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.