Question · asked by 1 review
Benzodiazepines (topical clonazepam) vs placebo: Adverse effects: dry mouth
- Population
- People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
- Intervention
- Benzodiazepines (topical clonazepam)
- Comparison
- placebo
- Outcome
- Adverse effects: dry mouth
It is very uncertain whether benzodiazepines (topical clonazepam) changes adverse effects: dry mouth compared with placebo (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Benzodiazepines (topical clonazepam) vs Placebo Adverse effects: dry mouth · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such… · short-term (up to 3 months), topical clonazepam It is very uncertain whether benzodiazepines (topical clonazepam) changes adverse effects: dry mouth compared with placebo (very low certainty). Interventions for treating burning mouth syndrome (2016) · Cochrane All outcomes | RR 3.00 [0.13, 70.16] | 1 study · 48 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes | 2015-12 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.