Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or: 4a.Death at any time during initial hospitalization – doxapram compared to no treatment for the treatment of apnea
- Population
- prevention of reintubation
- Intervention
- Doxapram
- Comparison
- no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or
- Outcome
- 4a.Death at any time during initial hospitalization – doxapram compared to no treatment for the treatment of apnea
It is very uncertain whether doxapram changes 4c. Death (at any time during initial hospitalization) – doxapram as… compared with no treatment, placebo, methylxanthine (including theophylline,… (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or 4c. Death (at any time during initial hospitalization) – doxapram as an adjunct to methylxanthine compared to methylxanthine alone for the prevention of reintubation · prevention of reintubation It is very uncertain whether doxapram changes 4c. Death (at any time during initial hospitalization) – doxapram as… compared with no treatment, placebo, methylxanthine (including theophylline,… (very low certainty). Doxapram for the prevention and treatment of apnea in preterm infants (2023) · Cochrane Headline outcomes only | RR 1.43 [0.34, 6.01] | 2 studies · 85 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Doxapram for the prevention and treatment of apnea in preterm infants 2023 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or · treatment of apnea · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.