Question · asked by 1 review
Carboxymethylcellulose (CMC) spray vs Placebo (spray base without CMC / water): Dry mouth (xerostomia)
- Population
- Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy, haemodialysis)
- Intervention
- Carboxymethylcellulose (CMC) spray
- Comparison
- Placebo (spray base without CMC / water)
- Outcome
- Dry mouth (xerostomia)
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Carboxymethylcellulose (CMC) spray vs Placebo (spray base without CMC / water) Xerostomia (oral dryness) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's… Interventions for the management of dry mouth: topical therapies (2011) · Cochrane All outcomes | Donatsky 1982 (crossover, n=15, Sjogren's syndrome): CMC spray had a similar effect on oral dryness to the spray base, but was more effective than water. Paired crossover data not presented; effect size not estimable. | 1 study · 15 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes | 2011-10 | Not listed | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Carboxymethylcellulose (CMC) spray vs Salinum linseed oil spray · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause… · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.