Question · asked by 1 review
Cetirizine 0.5 mg/kg/d vs placebo (18‐month intervention): Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period
- Population
- children with eczema
- Intervention
- Cetirizine 0.5 mg/kg/d
- Comparison
- placebo (18‐month intervention)
- Outcome
- Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period
Cetirizine 0.5 mg/kg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (18‐month intervention) (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Cetirizine 0.5 mg/kg/d vs placebo (18‐month intervention) Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period · children with eczema Cetirizine 0.5 mg/kg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (18‐month intervention) (moderate certainty). Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema (2019) · Cochrane Headline outcomes only | RR 0.68 [0.46, 1.01] | 1 study · 795 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.