Question · asked by 1 review
Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment: Maximal mouth opening (interincisal distance)
- Population
- People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
- Intervention
- Antioxidants (lycopene, curcumin, Oxitard)
- Comparison
- Placebo or no active treatment
- Outcome
- Maximal mouth opening (interincisal distance)
Antioxidants (lycopene, curcumin, Oxitard) showed no clear difference in maximal mouth opening (interincisal distance) compared with placebo or no active treatment (low certainty).
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 66.7%Moderate 1 · 33.3%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · More than 6 months Antioxidants (lycopene, curcumin, Oxitard) showed no clear difference in maximal mouth opening (interincisal distance) compared with placebo or no active treatment (low certainty). Interventions for managing oral submucous fibrosis (2024) · Cochrane All outcomes | MD -1.41 [-5.74, 2.92] | 1 study · 90 participants | Low |
Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months Antioxidants (lycopene, curcumin, Oxitard) may leads to higher maximal mouth opening (interincisal distance) compared with placebo or no active treatment (low certainty). Interventions for managing oral submucous fibrosis (2024) · Cochrane All outcomes | MD 3.11 [0.46, 5.77] | 2 studies · 520 participants | Low |
Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months Antioxidants (lycopene, curcumin, Oxitard) probably leads to higher maximal mouth opening (interincisal distance) compared with placebo or no active treatment (moderate certainty). Interventions for managing oral submucous fibrosis (2024) · Cochrane All outcomes | MD 8.83 [8.22, 9.45] | 3 studies · 620 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes | 2022-09 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.