Amoxicillin + metronidazole + SRP vs SRP: Clinical attachment level (CAL)
- Population
- Adults with periodontitis (chronic and aggressive)
- Intervention
- Amoxicillin + metronidazole + SRP
- Comparison
- SRP
- Outcome
- Clinical attachment level (CAL)
It is very uncertain whether amoxicillin + metronidazole + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Amoxicillin + metronidazole + SRP vs SRP Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) It is very uncertain whether amoxicillin + metronidazole + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty). Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane All outcomes | MD -0.47 [-0.90, -0.05] | 2 studies · 389 participants | Very low |
Amoxicillin + metronidazole + SRP vs SRP Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive) · Short-term (≤ 3 months) Amoxicillin + metronidazole + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported. Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane All outcomes | MD -0.21 [-0.41, -0.01] | 13 studies · 501 participants | GRADE not reported |
Amoxicillin + metronidazole + SRP vs SRP Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Amoxicillin + metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with SRP; GRADE not reported. Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane All outcomes | MD -0.04 [-0.35, 0.26] | 6 studies · 215 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes | 2020-03 | Not listed | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP · Adults with aggressive periodontitis · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.