Mepolizumab subcutaneous (SC) vs placebo: Rate of exacerbations requiring emergency department treatment or admission
Subcutaneous mepolizumab probably leads to lower rate of exacerbations requiring ED or admission compared with placebo (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Subcutaneous mepolizumab vs placebo Rate of exacerbations requiring ED or admission · adults with severe eosinophilic asthma Subcutaneous mepolizumab probably leads to lower rate of exacerbations requiring ED or admission compared with placebo (moderate certainty). Anti‐IL‐5 therapies for asthma (2015) · Cochrane Headline outcomes onlyearlier version CD010834.PUB2, superseded | Rate ratio 0.39 [0.18, 0.83] | 1 study · 385 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Anti‐IL‐5 therapies for asthma 2022 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.