Question · asked by 1 review
Irradiated carious dentin vs Non-irradiated carious dentin: MMP-2 expression/activity
- Population
- Human ex vivo carious dentin (head/neck radiotherapy)
- Intervention
- Irradiated carious dentin
- Comparison
- Non-irradiated carious dentin
- Outcome
- MMP-2 expression/activity
MMP-2 showed no difference between irradiated and non-irradiated carious dentin (one study; ungraded).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Irradiated carious dentin vs Non-irradiated carious dentin MMP-2 expression/activity · Human ex vivo carious dentin (head/neck radiotherapy) · Ex vivo (extracted teeth / clinical carious or biofilm samples) MMP-2 showed no difference between irradiated and non-irradiated carious dentin (one study; ungraded). Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex… (2023) All outcomes | No significant difference in MMP-2 (gelatinase) expression or activity between irradiated and non-irradiated groups (Gomes-Silva et al., 2017a); GRADE not separately applied to this comparison. | 1 study · 36 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies. 2023 All outcomes | March 2022 | 18 | Not applicable |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Irradiated carious dentin vs Non-irradiated carious dentin · Human carious dentin from irradiated and non-irradiated subjects · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.