Combined immune checkpoint inhibitors (ICIs) vs chemotherapy alone: Grades 3 and 4 adverse events
Combined immune checkpoint inhibitors (ICIs) showed no clear difference in adverse Events grade 3 to 4 compared with chemotherapy (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Combined immune checkpoint inhibitors (ICIs) vs chemotherapy Adverse Events grade 3 to 4 · people with advanced non‐small cell lung cancer Combined immune checkpoint inhibitors (ICIs) showed no clear difference in adverse Events grade 3 to 4 compared with chemotherapy (low certainty). Single or combined immune checkpoint inhibitors compared to first‐line platinum‐based chemotherapy with or… (2021) · Cochrane Headline outcomes only | RR 0.78 [0.55, 1.09] | 2 studies · 1869 participants | Low |
Combined immune checkpoint inhibitors (ICIs) vs chemotherapy Adverse Events grade 3 to 4 · people with advanced non‐small cell lung cancer Combined immune checkpoint inhibitors (ICIs) showed no clear difference in adverse Events grade 3 to 4 compared with chemotherapy (low certainty). Single or combined immune checkpoint inhibitors compared to first‐line platinum‐based chemotherapy with or… (2020) · Cochrane Headline outcomes onlyearlier version CD013257.PUB2, superseded | RR 0.78 [0.55, 1.09] | 2 studies · 1869 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Single or combined immune checkpoint inhibitors compared to first‐line platinum‐based chemotherapy with or without bevacizumab for people… 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.