Question · asked by 1 review
Systemic antibiotic (oral penicillin 500 mg) plus analgesic vs Placebo plus analgesic: Patient-reported pain intensity (sum of pain intensity difference (SPID) and sum of pain percussion intensity difference (SPPID))
- Population
- Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis
- Intervention
- Systemic antibiotic (oral penicillin 500 mg) plus analgesic
- Comparison
- Placebo plus analgesic
- Outcome
- Patient-reported pain intensity (sum of pain intensity difference (SPID) and sum of pain percussion intensity difference (SPPID))
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 1 · 25%Very low 0 · 0%Low 3 · 75%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Systemic antibiotic (oral penicillin 500 mg) plus analgesic vs Placebo plus analgesic Patient-reported pain intensity (sum of pain intensity difference (SPID) and sum of pain percussion intensity difference (SPPID)) · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis · 7 days Antibiotic use for irreversible pulpitis (2019) · Cochrane All outcomes | Corresponding risk (Antibiotics): The in between-group differences (median +/- IQR) in SPID for the penicillin group were 6.0 +/- 10.5, and for placebo 6.0 +/- 9.5. The SPPID for the penicillin group was 3.5 +/- 7.5… | 1 study · 40 participants | Low |
Systemic antibiotic (oral penicillin 500 mg) plus analgesic vs Placebo plus analgesic Patient-reported pain intensity (sum of pain intensity difference (SPID) and sum of pain percussion intensity difference (SPPID)) · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis · 7 days Antibiotic use for irreversible pulpitis (2016) · Cochrane All outcomesearlier version CD004969.PUB4, superseded | Illustrative comparative risks (Study population): Not estimable. Relative effect (95% CI): Not estimable. 40 (1 study). Quality: low. Comment: The in-between group differences in SPID and SPPID were not statistically… | 1 study · 40 participants | Low |
Systemic antibiotic (oral penicillin 500 mg) plus analgesic vs Placebo plus analgesic Patient-reported pain intensity (sum of pain intensity difference (SPID) and sum of pain percussion intensity difference (SPPID)) · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis · 7 days Antibiotic use for irreversible pulpitis (2013) · Cochrane All outcomesearlier version CD004969.PUB3, superseded | Illustrative comparative risks (Study population): Not estimable. Relative effect (95% CI): Not estimable. 40 (1 study). Quality: low. Comment: The in-between group differences in SPID and SPPID were not statistically… | 1 study · 40 participants | Low |
Systemic antibiotic (oral penicillin 500 mg) plus analgesic vs Placebo plus analgesic Patient-reported pain intensity (sum of pain intensity difference (SPID) and sum of pain percussion intensity difference (SPPID)) · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis · 7 days Antibiotic use for irreversible pulpitis (2005) · Cochrane All outcomesearlier version CD004969.PUB2, superseded | SPID (median +/- IQR): penicillin 6.0 +/- 10.5, placebo 6.0 +/- 9.5, P = 0.776. SPPID: penicillin 3.5 +/- 7.5, placebo 2.0 +/- 7.0, P = 0.290 (Mann-Whitney-Wilcoxon). Between-group differences not statistically… | 1 study · 40 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antibiotic use for irreversible pulpitis 2019 · Cochrane All outcomes | 2019-02 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.