Combination fluticasone/salmeterol vs budesonide/formoterol: Asthma‐related serious adverse event
Combination fluticasone/salmeterol showed no clear difference in asthma‐related serious adverse event compared with budesonide/formoterol (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Combination fluticasone/salmeterol vs budesonide/formoterol Asthma‐related serious adverse event · Patients with chronic asthma in adults and children Combination fluticasone/salmeterol showed no clear difference in asthma‐related serious adverse event compared with budesonide/formoterol (moderate certainty). Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic… (2011) · Cochrane Headline outcomes only | OR 1.47 [0.75, 2.86] | 3 studies · 4054 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in adults and children 2011 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.