Question · asked by 1 review

Clobetasol propionate plus miconazole (adjunctive antifungal) vs Clobetasol propionate plus placebo: Pain (mean score)

Population
People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
Intervention
Clobetasol propionate plus miconazole (adjunctive antifungal)
Comparison
Clobetasol propionate plus placebo
Outcome
Pain (mean score)

What each review found

Current versions only
No studies found 0 · 0%GRADE not reported 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
FindingEffectStudiesGRADE certainty
Clobetasol propionate plus miconazole (adjunctive antifungal) vs Clobetasol propionate plus placebo
Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
Interventions for treating oral lichen planus: corticosteroid therapies (2020) · Cochrane All outcomes
Lodi 2007: no benefit of adjunctive miconazole for pain (low to very low certainty collectively)1 studyGRADE not reported
Clobetasol propionate plus miconazole (adjunctive antifungal) vs Clobetasol propionate plus placebo
Pain (mean score) · Patients with a clinical and histological diagnosis of symptomatic oral lichen planus (OLP); not concurrently taking…
Interventions for treating oral lichen planus: corticosteroid therapies (2011) · Cochrane All outcomesearlier version CD001168.PUB2, superseded
Lodi 2007: no difference in pain between clobetasol with vs without miconazole1 studyGRADE not reported

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Interventions for treating oral lichen planus: corticosteroid therapies
2020 · Cochrane All outcomes
2019-02Not listedNot assessed
How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.