Question · asked by 1 review
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848: Dental caries susceptibility
- Population
- Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
- Intervention
- AG + GG genotype (G-allele carriers) of ENAM rs1264848
- Comparison
- AA genotype of ENAM rs1264848
- Outcome
- Dental caries susceptibility
No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of ENAM rs1264848 and dental caries susceptibility (AG + GG vs AA model: OR 1.69, 95% CI 0.78-3.68) in the Ethnicity: Mixed subgroup; certainty not graded.
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 6 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Ethnicity: Mixed No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of ENAM rs1264848 and dental caries susceptibility (AG + GG vs AA model: OR 1.69, 95% CI 0.78-3.68) in the Ethnicity: Mixed subgroup; certainty not graded. Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes | OR 1.69 [0.78, 3.68] | 1 study | GRADE not reported |
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Age group: Children No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of ENAM rs1264848 and dental caries susceptibility (AG + GG vs AA model: OR 1.16, 95% CI 0.76-1.75) in the Age group: Children subgroup; certainty not graded. Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes | OR 1.16 [0.76, 1.75] | 4 studies | GRADE not reported |
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Ethnicity: Caucasian No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of ENAM rs1264848 and dental caries susceptibility (AG + GG vs AA model: OR 1.18, 95% CI 0.86-1.62) in the Ethnicity: Caucasian subgroup; certainty not graded. Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes | OR 1.18 [0.86, 1.62] | 4 studies | GRADE not reported |
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Control group: Low caries No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of ENAM rs1264848 and dental caries susceptibility (AG + GG vs AA model: OR 1.45, 95% CI 0.92-2.28) in the Control group: Low caries subgroup; certainty not graded. Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes | OR 1.45 [0.92, 2.28] | 2 studies | GRADE not reported |
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Control group: Caries-free No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of ENAM rs1264848 and dental caries susceptibility (AG + GG vs AA model: OR 0.74, 95% CI 0.27-2.02) in the Control group: Caries-free subgroup; certainty not graded. Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes | OR 0.74 [0.27, 2.02] | 3 studies | GRADE not reported |
AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Overall No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of ENAM rs1264848 and dental caries susceptibility (AG + GG vs AA model: OR 1.24, 95% CI 0.93-1.67); certainty not graded. Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes | OR 1.24 [0.93, 1.67] | 5 studies · 1534 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes | Up to October 2019 | 16 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.