Question · asked by 1 review

Chemotherapy vs no chemotherapy: Mortality at maximal

It is very uncertain whether chemotherapy changes mortality (at maximal compared with no chemotherapy (very low certainty).

What each review found

Current versions only
FindingEffectStudiesGRADE certainty
Chemotherapy vs no chemotherapy
Mortality (at maximal · people with intermediate‐stage hepatocellular carcinoma
It is very uncertain whether chemotherapy changes mortality (at maximal compared with no chemotherapy (very low certainty).
Management of people with intermediate‐stage hepatocellular carcinoma (2017) · Cochrane Headline outcomes only
HR 0.85 [0.6, 1.18]2 studies · 412 participantsVery low

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Management of people with intermediate‐stage hepatocellular carcinoma
2017 · Cochrane Headline outcomes only
Not reportedlist not extracted yetNot assessed

Studies behind the findings

None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.

How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.