N‐acetylcysteine vs placebo: Withdrawals due to adverse events
- Population
- cannabis dependence
- Intervention
- N‐acetylcysteine
- Comparison
- placebo
- Outcome
- Withdrawals due to adverse events
N‐acetylcysteine showed no clear difference in participants withdrawn due to adverse effects compared with placebo (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
N‐acetylcysteine vs placebo Participants withdrawn due to adverse effects · cannabis dependence N‐acetylcysteine showed no clear difference in participants withdrawn due to adverse effects compared with placebo (low certainty). Pharmacotherapies for cannabis dependence (2019) · Cochrane Headline outcomes only | RR 3 [0.12, 72.15] | 1 study · 116 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- N‐acetylcysteine vs placebo · adults (aged 18 years+) with depression in bipolar disorder · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.