Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention: Severe intraventricular haemorrhage
- Population
- neonates with sepsis
- Intervention
- Pentoxifylline with antibiotics (any dose or duration)
- Comparison
- placebo or no intervention
- Outcome
- Severe intraventricular haemorrhage
It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes severe intraventricular haemorrhage compared with placebo or no intervention (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention Severe intraventricular haemorrhage · neonates with sepsis It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes severe intraventricular haemorrhage compared with placebo or no intervention (very low certainty). Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates (2023) · Cochrane Headline outcomes only | RR 0.75 [0.28, 2.03] | 1 study · 120 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics · neonates with sepsis · 1 review
- Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin · neonates with sepsis · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.