Extended‐fixed vs monthly injections: Gain of 3 or more lines of visual acuity
Extended‐fixed showed no clear difference in gain of ≥ 15 letters visual acuity at 1 year compared with monthly injections (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Extended‐fixed vs monthly injections Gain of ≥ 15 letters visual acuity at 1 year · people with neovascular age‐related macular degeneration Extended‐fixed showed no clear difference in gain of ≥ 15 letters visual acuity at 1 year compared with monthly injections (moderate certainty). Treatment regimens for administration of anti‐vascular endothelial growth factor agents for neovascular… (2020) · Cochrane Headline outcomes only | RR 0.94 [0.8, 1.1] | 3 studies · 1441 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Treatment regimens for administration of anti‐vascular endothelial growth factor agents for neovascular age‐related macular degeneration 2020 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.