Rotarix vs placebo: Severe cases of rotavirus diarrhoea
Rotarix leads to lower severe cases of rotavirus diarrhoea compared with placebo (high certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Rotarix vs placebo Severe cases of rotavirus diarrhoea · children Rotarix leads to lower severe cases of rotavirus diarrhoea compared with placebo (high certainty). Vaccines for preventing rotavirus diarrhoea: vaccines in use (2021) · Cochrane Headline outcomes only | RR 0.07 [0.03, 0.18] | 4 studies · 14976 participants | High |
Rotarix vs placebo Severe cases of rotavirus diarrhoea · children Rotarix leads to lower severe cases of rotavirus diarrhoea compared with placebo (high certainty). Vaccines for preventing rotavirus diarrhoea: vaccines in use (2021) · Cochrane Headline outcomes only | RR 0.42 [0.28, 0.61] | 4 studies · 15822 participants | High |
Rotarix vs placebo Severe cases of rotavirus diarrhoea · children Rotarix probably leads to lower severe cases of rotavirus diarrhoea compared with placebo (moderate certainty). Vaccines for preventing rotavirus diarrhoea: vaccines in use (2021) · Cochrane Headline outcomes only | RR 0.65 [0.51, 0.83] | 2 studies · 13768 participants | Moderate |
Rotarix vs placebo Severe cases of rotavirus diarrhoea · children Rotarix leads to lower severe cases of rotavirus diarrhoea compared with placebo (high certainty). Vaccines for preventing rotavirus diarrhoea: vaccines in use (2021) · Cochrane Headline outcomes only | RR 0.1 [0.07, 0.14] | 6 studies · 18145 participants | High |
Rotarix vs placebo Severe cases of rotavirus diarrhoea · children Rotarix leads to lower severe cases of rotavirus diarrhoea compared with placebo (high certainty). Vaccines for preventing rotavirus diarrhoea: vaccines in use (2021) · Cochrane Headline outcomes only | RR 0.21 [0.16, 0.29] | 4 studies · 31671 participants | High |
Rotarix vs placebo Severe cases of rotavirus diarrhoea · children Rotarix leads to lower severe cases of rotavirus diarrhoea compared with placebo (high certainty). Vaccines for preventing rotavirus diarrhoea: vaccines in use (2021) · Cochrane Headline outcomes only | RR 0.23 [0.17, 0.29] | 3 studies · 23834 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.