Oral 5‐ASA vs 5‐aminosalicylic acid (5‐ASA) (mesalazine): Adverse events
Oral 5‐ASA showed no clear difference in adverse events compared with comparator 5‐ASA (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Oral 5‐ASA vs comparator 5‐ASA Adverse events · People with active mild‐to‐moderate ulcerative colitis Oral 5‐ASA showed no clear difference in adverse events compared with comparator 5‐ASA (moderate certainty). Oral 5‐aminosalicylic acid for induction of remission in ulcerative colitis (2020) · Cochrane Headline outcomes only | RR 1.01 [0.92, 1.12] | 9 studies · 1576 participants | Moderate |
Oral 5‐ASA vs comparator 5‐ASA Adverse events · Patients with active mild to moderate ulcerative colitis Oral 5‐ASA showed no clear difference in adverse events compared with comparator 5‐ASA (moderate certainty). Oral 5‐aminosalicylic acid for induction of remission in ulcerative colitis (2016) · Cochrane Headline outcomes onlyearlier version CD000543.PUB4, superseded | RR 1.01 [0.92, 1.12] | 9 studies · 1576 participants | Moderate |
Oral 5‐ASA vs comparator 5‐ASA Adverse events · Patients with active mild to moderate ulcerative colitis Oral 5‐ASA showed no clear difference in adverse events compared with comparator 5‐ASA (moderate certainty). Oral 5‐aminosalicylic acid for induction of remission in ulcerative colitis (2012) · Cochrane Headline outcomes onlyearlier version CD000543.PUB3, superseded | RR 1.01 [0.92, 1.12] | 9 studies · 1576 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Oral 5‐aminosalicylic acid for induction of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.