Question · asked by 1 review

Outer carious dentin (by lesion depth/location) vs Inner carious dentin: MMP-20 location/depth (outer vs inner)

Population: Human ex vivo carious dentin
Intervention: Outer carious dentin (by lesion depth/location)
Comparison: Inner carious dentin
Outcome: MMP-20 location/depth (outer vs inner)

MMP-20 probably decreases in outer compared with inner carious dentin (moderate certainty).

What each review found

Finding	Effect	Studies	GRADE certainty
Outer carious dentin (by lesion depth/location) vs Inner carious dentin MMP-20 location/depth (outer vs inner) · Human ex vivo carious dentin · Ex vivo (extracted teeth / clinical carious or biofilm samples) MMP-20 probably decreases in outer compared with inner carious dentin (moderate certainty). Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex… (2023) All outcomes	MMP-20 probably reduces in carious outer dentin when compared to carious inner dentin (moderate certainty); MMP-20 was significantly lower in outer dentin than inner (Shimada et al., 2009).	1 study · 5 participants	Moderate

Findings are shown side by side, never pooled across reviews.

The reviews

Review	Searched up to	Included studies	AMSTAR 2
Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies. 2023 All outcomes	March 2022	18	Not applicable

How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.