Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs Antifungal drugs not absorbed from GI tract: Toxicity (adverse events probably due to drug)
- Population
- Patients with cancer receiving chemotherapy and/or radiotherapy
- Intervention
- Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole)
- Comparison
- Antifungal drugs not absorbed from GI tract
- Outcome
- Toxicity (adverse events probably due to drug)
Antifungal drugs absorbed from GI tract showed no clear difference in toxicity (adverse events probably due to drug) compared with antifungal drugs not absorbed from GI tract; GRADE not reported.
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Antifungal drugs absorbed from GI tract vs Antifungal drugs not absorbed from GI tract Toxicity (adverse events probably due to drug) · Patients with cancer receiving chemotherapy or radiotherapy or both Antifungal drugs absorbed from GI tract showed no clear difference in toxicity (adverse events probably due to drug) compared with antifungal drugs not absorbed from GI tract; GRADE not reported. Interventions for preventing oral candidiasis for patients with cancer receiving treatment (2007) · Cochrane All outcomes | RR 0.88 [0.33, 2.3] | 6 studies · 2018 participants | GRADE not reported |
Antifungal drugs absorbed from GI tract vs Antifungal drugs not absorbed from GI tract Toxicity (adverse events probably due to drug) · Patients with cancer receiving chemotherapy and/or radiotherapy Antifungal drugs absorbed from GI tract showed no clear difference in toxicity (adverse events probably due to drug) compared with antifungal drugs not absorbed from GI tract; GRADE not reported. Interventions for preventing oral candidiasis for patients with cancer receiving treatment (2004) · Cochrane All outcomesearlier version CD003807.PUB2, superseded | RR 0.88 [0.33, 2.3] | 6 studies · 2018 participants | GRADE not reported |
Antifungal drugs absorbed from GI tract vs Antifungal drugs not absorbed from GI tract Toxicity (adverse events probably due to drug) · Patients with cancer receiving chemotherapy and/or radiotherapy Antifungal drugs absorbed from GI tract showed no clear difference in toxicity (adverse events probably due to drug) compared with antifungal drugs not absorbed from GI tract; GRADE not reported. Interventions for preventing oral candidiasis for patients with cancer receiving treatment (2002) · Cochrane All outcomesearlier version CD003807, superseded | RR 0.99 [0.35, 2.81] | 5 studies · 1929 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for preventing oral candidiasis for patients with cancer receiving treatment 2007 · Cochrane All outcomes | 2009-08 | Not listed | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment · Patients with cancer receiving chemotherapy and/or radiotherapy · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.