Tiotropium vs placebo: Exacerbations (number of people experiencing ≥ 1 exacerbations)
Tiotropium leads to lower number of patients with one or more exacerbations compared with placebo (high certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Tiotropium vs placebo Number of patients with one or more exacerbations · people with COPD who have smoked for ≥ 10 pack‐years Tiotropium leads to lower number of patients with one or more exacerbations compared with placebo (high certainty). Tiotropium versus placebo for chronic obstructive pulmonary disease (2014) · Cochrane Headline outcomes only | OR 0.78 [0.7, 0.87] | 22 studies · 23309 participants | High |
Tiotropium vs placebo Number of patients with one or more exacerbations · people with COPD who have smoked for ≥ 10 pack‐years Tiotropium leads to lower number of patients with one or more exacerbations compared with placebo (high certainty). Tiotropium versus placebo for chronic obstructive pulmonary disease (2012) · Cochrane Headline outcomes onlyearlier version CD009285.PUB2, superseded | OR 0.78 [0.7, 0.87] | 22 studies · 23309 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Tiotropium versus placebo for chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.