Question · asked by 1 review
Before cavity sealing vs After cavity sealing: MMP-2 expression/activity
- Population
- Human carious dentin
- Intervention
- Before cavity sealing
- Comparison
- After cavity sealing
- Outcome
- MMP-2 expression/activity
No difference in MMP-2 expression/activity was found before versus after cavity sealing (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Before cavity sealing vs After cavity sealing MMP-2 expression/activity · Human carious dentin · 60 days after cavity sealing No difference in MMP-2 expression/activity was found before versus after cavity sealing (very low certainty). Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex… (2023) All outcomes | no estimate extracted | 2 studies · 48 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies. 2023 All outcomes | March 2022 | 18 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.