Metformin vs glibenclamide ‐ neonatal outcomes: Perinatal mortality
- Population
- Infants of women diagnosed with gestational diabetes
- Intervention
- Metformin
- Comparison
- glibenclamide ‐ neonatal outcomes
- Outcome
- Perinatal mortality
It is very uncertain whether metformin changes perinatal mortality compared with glibenclamide ‐ neonatal outcomes (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Metformin vs glibenclamide ‐ neonatal outcomes Perinatal mortality · Infants of women diagnosed with gestational diabetes It is very uncertain whether metformin changes perinatal mortality compared with glibenclamide ‐ neonatal outcomes (very low certainty). Oral anti‐diabetic pharmacological therapies for the treatment of women with gestational diabetes (2017) · Cochrane Headline outcomes only | RR 0.92 [0.06, 14.55] | 2 studies · 359 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Oral anti‐diabetic pharmacological therapies for the treatment of women with gestational diabetes 2017 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Metformin vs insulin · women with type 2 diabetes · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.