Question · asked by 1 review
Amoxicillin + metronidazole + SRP vs SRP: Percentage of closed pockets
- Population
- Adults with periodontitis (chronic and aggressive)
- Intervention
- Amoxicillin + metronidazole + SRP
- Comparison
- SRP
- Outcome
- Percentage of closed pockets
Amoxicillin + metronidazole + SRP led to lower percentage of closed pockets compared with SRP; GRADE not reported.
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 2 · 66.7%Very low 1 · 33.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Amoxicillin + metronidazole + SRP vs SRP Percentage of closed pockets · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Amoxicillin + metronidazole + SRP led to lower percentage of closed pockets compared with SRP; GRADE not reported. Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane All outcomes | MD -13.90 [-24.16, -3.64] | 1 study · 44 participants | GRADE not reported |
Amoxicillin + metronidazole + SRP vs SRP Percentage of closed pockets · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) It is very uncertain whether amoxicillin + metronidazole + SRP changes percentage of closed pockets compared with SRP (very low certainty). Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane All outcomes | MD -16.20 [-25.87, -6.53] | 1 study · 44 participants | Very low |
Amoxicillin + metronidazole + SRP vs SRP Percentage of closed pockets · Adults with periodontitis (chronic and aggressive) · Short-term (≤ 3 months) Amoxicillin + metronidazole + SRP led to lower percentage of closed pockets compared with SRP; GRADE not reported. Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane All outcomes | MD -10.05 [-18.78, -1.32] | 2 studies · 73 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes | 2020-03 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.