Question · asked by 1 review
Systemic oral acyclovir vs placebo or no treatment: Duration and time of healing of intraoral (oral) lesions; number of individuals with oral lesions
- Population
- Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
- Intervention
- Systemic oral acyclovir
- Comparison
- placebo or no treatment
- Outcome
- Duration and time of healing of intraoral (oral) lesions; number of individuals with oral lesions
Systemic oral acyclovir led to lower number of individuals with oral lesions (8 days after… compared with placebo or no treatment; GRADE not reported.
What each review found
Current versions onlyNo studies found 1 · 50%GRADE not reported 1 · 50%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Systemic oral acyclovir vs Placebo or no treatment Number of individuals with oral lesions (8 days after administration); time to healing of oral lesions · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis) · 8 days after administration Systemic oral acyclovir led to lower number of individuals with oral lesions (8 days after… compared with placebo or no treatment; GRADE not reported. Acyclovir for treating primary herpetic gingivostomatitis (2008) · Cochrane All outcomes | RR 0.10 [0.02, 0.38] | 1 study · 72 participants | GRADE not reported |
Systemic oral acyclovir vs Placebo or no treatment Duration and time of healing of intraoral (oral) lesions; number of individuals with oral lesions · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis) The review found no eligible studies for this question. Acyclovir for treating primary herpetic gingivostomatitis (2007) · Cochrane All outcomesearlier version CD006700, superseded | Protocol primary outcome: duration and time of healing of all intraoral and extraoral lesions from time of administration of intervention; change in number of lesions and number of individuals with lesions. | Not reported | No studies found |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Acyclovir for treating primary herpetic gingivostomatitis 2008 · Cochrane All outcomes | 2008-05 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.