Oral midazolam vs placebo or no intervention: Behaviour
- Population
- Children and adolescents (0 to 16 years) needing dental treatment
- Intervention
- Oral midazolam
- Comparison
- placebo or no intervention
- Outcome
- Behaviour
Oral midazolam probably leads to higher behaviour (Houpt/behavioural score) compared with placebo (including no intervention) (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Oral midazolam vs Placebo (including no intervention) Behaviour (Houpt/behavioural score) · Children and adolescents (0 to 16 years) needing dental treatment Oral midazolam probably leads to higher behaviour (Houpt/behavioural score) compared with placebo (including no intervention) (moderate certainty). Sedation of children undergoing dental treatment (2018) · Cochrane All outcomes | SMD 1.96 [1.59, 2.33] | 6 studies · 202 participants | Moderate |
Oral midazolam vs Placebo (including no intervention) Behaviour · Children and adolescents (0 to 16 years) needing dental treatment Oral midazolam led to higher behaviour compared with placebo (including no intervention); GRADE not reported. Sedation of children undergoing dental treatment (2012) · Cochrane All outcomesearlier version CD003877.PUB4, superseded | SMD 2.98 [1.58, 4.37] | 5 studies · 182 participants | GRADE not reported |
Oral midazolam vs Placebo (including no intervention) Behaviour · Children and adolescents (0 to 16 years) needing dental treatment Sedation of children undergoing dental treatment (2006) · Cochrane All outcomesearlier version CD003877.PUB3, superseded | Two studies (Gallardo 1994; Lima 2003) reported oral midazolam significantly improved all parameters vs placebo; a further study (Kapur 2004) of oral transmucosal midazolam also found significant differences favouring… | 2 studies | GRADE not reported |
Oral midazolam vs Placebo (including no intervention) Behaviour · Children and adolescents (0 to 16 years) needing dental treatment Sedation of children undergoing dental treatment (2005) · Cochrane All outcomesearlier version CD003877.PUB2, superseded | Gallardo 1994 (oral midazolam 7.5 mg): significantly improved all parameters evaluated vs placebo. Narrative; not pooled. | 1 study | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Sedation of children undergoing dental treatment 2018 · Cochrane All outcomes | 22 February 2018 | Not listed | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Oral midazolam vs A different sedative agent · Children and adolescents (0 to 16 years) needing dental treatment · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.