Dornase alfa vs after airway clearance techniques: FVC (% predicted) Change from baseline
Inhalation of dornase alfa before showed no clear difference in FVC (% predicted) change from baseline compared with after airway clearance techniques (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Inhalation of dornase alfa before vs after airway clearance techniques FVC (% predicted) change from baseline · adults and children with cystic fibrosis Inhalation of dornase alfa before showed no clear difference in FVC (% predicted) change from baseline compared with after airway clearance techniques (low certainty). Timing of dornase alfa inhalation for cystic fibrosis (2021) · Cochrane Headline outcomes only | MD 1.06 | 77 participants | Low |
Inhalation of dornase alfa before vs after airway clearance techniques FVC (% predicted) change from baseline · adults and children with cystic fibrosis Inhalation of dornase alfa before showed no clear difference in FVC (% predicted) change from baseline compared with after airway clearance techniques (low certainty). Timing of dornase alfa inhalation for cystic fibrosis (2018) · Cochrane Headline outcomes onlyearlier version CD007923.PUB5, superseded | MD 1.06 | 77 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Timing of dornase alfa inhalation for cystic fibrosis 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.