Doxycycline + SRP vs Amoxicillin + metronidazole + SRP: Adverse events
- Population
- Adults with aggressive periodontitis
- Intervention
- Doxycycline + SRP
- Comparison
- Amoxicillin + metronidazole + SRP
- Outcome
- Adverse events
Doxycycline + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Doxycycline + SRP vs Amoxicillin + metronidazole + SRP Adverse events · Adults with aggressive periodontitis Doxycycline + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported. Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane All outcomes | One trial (Akincibay 2008) did not report this outcome; Xajigeorgiou 2006 reported mild gastrointestinal discomfort in 2 subjects from the AMOX + MTZ + SRP group. | 1 study | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes | 2020-03 | Not listed | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Doxycycline + SRP vs Metronidazole + SRP · Adults with aggressive periodontitis · 1 review
- Doxycycline + SRP vs SRP · Adults with aggressive periodontitis · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.