Question · asked by 1 review
Phentermine/topiramate vs placebo: All adverse events
- Population
- Men and non‐pregnant women ≥ 18 years old with essential hypertension
- Intervention
- Phentermine/topiramate
- Comparison
- placebo
- Outcome
- All adverse events
Phentermine/topiramate may leads to higher all adverse events compared with placebo (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Phentermine/topiramate vs placebo All adverse events · Men and non‐pregnant women ≥ 18 years old with essential hypertension Phentermine/topiramate may leads to higher all adverse events compared with placebo (low certainty). Long‐term effects of weight‐reducing drugs in people with hypertension (2021) · Cochrane Headline outcomes only | RR 1.13 [1.08, 1.2] | 1 study · 1305 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Long‐term effects of weight‐reducing drugs in people with hypertension 2021 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.