Azathioprine or 6‐mercaptopurine vs methotrexate: Withdrawals due to adverse events
It is very uncertain whether azathioprine or 6‐mercaptopurine changes withdrawals due to adverse events compared with methotrexate (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Azathioprine or 6‐mercaptopurine vs methotrexate Withdrawals due to adverse events · Patients with active Crohn's disease It is very uncertain whether azathioprine or 6‐mercaptopurine changes withdrawals due to adverse events compared with methotrexate (very low certainty). Azathioprine or 6‐mercaptopurine for induction of remission in Crohn's disease (2016) · Cochrane Headline outcomes only | RR 0.78 [0.23, 2.71] | 2 studies · 85 participants | Very low |
Azathioprine or 6‐mercaptopurine vs methotrexate Withdrawals due to adverse events · Patients with active Crohn's disease It is very uncertain whether azathioprine or 6‐mercaptopurine changes withdrawals due to adverse events compared with methotrexate (very low certainty). Azathioprine or 6‐mercaptopurine for induction of remission in Crohn's disease (2013) · Cochrane Headline outcomes onlyearlier version CD000545.PUB4, superseded | RR 0.78 [0.23, 2.71] | 2 studies · 85 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Azathioprine or 6‐mercaptopurine for induction of remission in Crohn's disease 2016 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.