Question · asked by 1 review
Dornase alfa vs alternate days: Pulmonary exacerbations
- Population
- children with cystic fibrosis
- Intervention
- Dornase alfa
- Comparison
- alternate days
- Outcome
- Pulmonary exacerbations
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 100%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Dornase alfa daily vs alternate days Number of pulmonary exacerbations at 3 months · Children with cystic fibrosis Dornase alfa for cystic fibrosis (2021) · Cochrane Headline outcomes only | no estimate extracted | 43 participants | Low |
Dornase alfa daily vs alternate days Number of pulmonary exacerbations at 3 months · Children with cystic fibrosis Dornase alfa for cystic fibrosis (2018) · Cochrane Headline outcomes onlyearlier version CD001127.PUB4, superseded | no estimate extracted | 43 participants | Low |
Dornase alfa daily vs alternate days Number of pulmonary exacerbations at 3 months · Children with cystic fibrosis Dornase alfa for cystic fibrosis (2016) · Cochrane Headline outcomes onlyearlier version CD001127.PUB3, superseded | no estimate extracted | 43 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Dornase alfa for cystic fibrosis 2021 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Dornase alfa vs hypertonic saline · children with cystic fibrosis · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.