Question · asked by 1 review
Low molecular weight heparin vs vitamin K antagonist (VKA): Major bleeding
- Population
- people with cancer with thrombosis prophylaxis and central venous catheters
- Intervention
- Low molecular weight heparin
- Comparison
- vitamin K antagonist (VKA)
- Outcome
- Major bleeding
It is very uncertain whether low‐molecular‐weight heparin (LMWH) changes major bleeding (up to 3 months) compared with vitamin K antagonist (VKA) (very low certainty).
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 50%Low 2 · 50%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Low‐molecular‐weight heparin (LMWH) vs vitamin K antagonist (VKA) Major bleeding (up to 3 months) · people with cancer with thrombosis prophylaxis and central venous catheters It is very uncertain whether low‐molecular‐weight heparin (LMWH) changes major bleeding (up to 3 months) compared with vitamin K antagonist (VKA) (very low certainty). Anticoagulation for people with cancer and central venous catheters (2018) · Cochrane Headline outcomes only | RR 3.11 [0.13, 73.11] | 2 studies · 289 participants | Very low |
Low‐molecular‐weight heparin (LMWH) vs vitamin K antagonist (VKA) Major bleeding · people with cancer with thrombosis prophylaxis and central venous catheters It is very uncertain whether low‐molecular‐weight heparin (LMWH) changes major bleeding compared with vitamin K antagonist (VKA) (very low certainty). Anticoagulation for people with cancer and central venous catheters (2014) · Cochrane Headline outcomes onlyearlier version CD006468.PUB5, superseded | RR 3.41 [0.15, 79.47] | 2 studies · 279 participants | Very low |
LMWH vs VKA Major bleeding · patients with thrombosis prophylaxis in cancer patients with central venous catheters LMWH showed no clear difference in major bleeding compared with VKA (low certainty). Anticoagulation for people with cancer and central venous catheters (2011) · Cochrane Headline outcomes onlyearlier version CD006468.PUB3, superseded | RR 3.1 [0.13, 73.14] | 2 studies · 343 participants | Low |
LMWH vs VKA Major bleeding · patients with thrombosis prophylaxis in cancer patients with central venous catheters LMWH showed no clear difference in major bleeding compared with VKA (low certainty). Anticoagulation for people with cancer and central venous catheters (2011) · Cochrane Headline outcomes onlyearlier version CD006468.PUB4, superseded | RR 3.1 [0.13, 73.14] | 2 studies · 343 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Anticoagulation for people with cancer and central venous catheters 2018 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
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- Low molecular weight heparin vs UFH · patients with the initial treatment of venous thromboembolism in patients with cancer · 0 reviews
- Low molecular weight heparin vs UFH · People with cancer with perioperative thromboprophylaxis · 0 reviews
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.