Carious dentin vs Sound dentin: Cathepsin B (CT-B) presence/activity
- Population
- Human ex vivo carious dentin (mostly coronal), natural caries lesions
- Intervention
- Carious dentin
- Comparison
- Sound dentin
- Outcome
- Cathepsin B (CT-B) presence/activity
Cathepsin B may be increased in carious dentin compared with sound dentin, but the evidence is very uncertain (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Carious dentin vs Sound dentin Cathepsin B (CT-B) presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions · Ex vivo (extracted teeth / clinical carious or biofilm samples) Cathepsin B may be increased in carious dentin compared with sound dentin, but the evidence is very uncertain (very low certainty). Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex… (2023) All outcomes | CT-B may be increased in carious dentin when compared to sound dentin, but the evidence is very uncertain (Vidal et al., 2014; Nascimento et al., 2011: significantly higher in caries, p<0.05). | 2 studies · 22 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies. 2023 All outcomes | March 2022 | 18 | Not applicable |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Carious dentin vs Sound dentin · Human coronal carious dentin and sound dentin · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.