Methotrexate + infliximab vs infliximab: Failure to enter remission at 14 weeks or 24 weeks (Feagan 2014)
Methotrexate + infliximab showed no clear difference in failure to enter remission at 14 weeks or 24 weeks (Feagan 2014) compared with infliximab alone (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Methotrexate + infliximab vs infliximab alone Failure to enter remission at 14 weeks or 24 weeks (Feagan 2014) · adult patients with refractory Crohn's disease Methotrexate + infliximab showed no clear difference in failure to enter remission at 14 weeks or 24 weeks (Feagan 2014) compared with infliximab alone (low certainty). Methotrexate for induction of remission in refractory Crohn's disease (2014) · Cochrane Headline outcomes only | RR 1.07 [0.57, 2.03] | 1 study · 126 participants | Low |
Methotrexate + infliximab vs infliximab alone Failure to enter remission at 14 weeks or 24 weeks (Schröder 2006) · adult patients with refractory Crohn's disease It is very uncertain whether methotrexate + infliximab changes failure to enter remission at 14 weeks or 24 weeks (Schröder 2006) compared with infliximab alone (very low certainty). Methotrexate for induction of remission in refractory Crohn's disease (2014) · Cochrane Headline outcomes only | RR 0.73 [0.31, 1.69] | 1 study · 19 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Methotrexate for induction of remission in refractory Crohn's disease 2014 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.